Pre-formulation and Formulation Services

DPT scientists combine decades of drug formulation expertise with an extensive understanding of commercial pharmaceutical manufacturing processes to help our customers develop and commercialize drug products in semi-solid and liquid dosage forms.

Pre-formulation Services

• Raw material sourcing
• Solubility profile (in buffers and non-aqueous solvents) and partition coefficient of API
• API compatibility with excipients
• Stability of API and factors affecting stability (including heat, light, and pH)
• Method development and method transfer for particle size of wet and dry particles by laser diffraction (for both API and the formulation)
• API characterization by DSC, powder X-ray diffraction, FTIR and particle morphology by optical microscopy
• Formulation and packaging compatibility
• Surface tension of aqueous and non-aqueous liquids

Formulation Services

• Particle size (dry, wet, and sprays)
• Rheology/viscosity
• pH
• Specific gravity
• Informal stability/Formulation stress testing (both physical and chemical)
• Antimicrobial Effectiveness Testing (AET)
• Formulation container closure compatibility assessment